Two Experts: One Epic Longevity Conversation

When Dr. Mark Hyman and Dr. Jeff Bland sit down to record a podcast, hang onto your seat and stand by for revelations that will get you thinking about your health in entirely new ways. These two thought leaders recently came together for a conversation, and here’s the radically empowering idea that emerged: aging is not fixed—it's fluid, and it starts in the immune system.

At 79 years old, Dr. Bland’s biological age is 62. His secret? Not anti-aging, but Immuno-Rejuvenation—a concept grounded in the body's capacity to renew itself from the inside out, especially through the immune system, mitochondria, and metabolic pathways.

Here are the highlights:

Longevity Begins in the Immune System
Our immune cells regenerate every 90 to 120 days. If they regenerate worse each time, we age. But what if we could regenerate better? That’s the goal of Immuno-Rejuvenation—restoring balance, not “boosting” immunity.

The “Trio of Transformation”
Gut restoration, metabolic detoxification, and mitochondrial resuscitation are foundational. But Dr. Bland believes the next frontier is enhancing immune adaptability through lifestyle, nutrients, and targeted polyphenols.

The Power of Epigenetics + Food
Our genes are fixed, but how they express isn’t. Food—especially polyphenol-rich foods like Himalayan Tartary Buckwheat—can influence immune gene activity, promote resilience, and even reverse biological aging. Dr. Bland and his colleagues recently put the Food-is-Medicine concept to the test—and it passed with flying colors. Learn more about a clinical study Dr. Bland conducted that demonstrated a 47% reduction in the rate of aging in a cohort of study subjects by clicking HERE.

The Future: Measuring and Managing Healthspan
Dr. Hyman highlighted new platforms like Function Health, where consumers track 20M+ biomarkers to catch imbalances decades before symptoms arise. It’s a shift from disease care to self-powered prevention.

What’s the takeaway? Longevity is not just a number—it’s a narrative. You’re not stuck with the genes you’ve got—or the immune system you had last year. Aging well is possible when you engage your biology with intelligence and intention.

Resources

Access the full podcast episode HERE.

Dr. Austin Perlmutter’s 2024 webinar, Slow Aging. Watch for free on YouTube.

Wondering about your current immune status? Take Big Bold Health’s free Immuno-Identity Quiz by clicking HERE.

Follow these Instagram accounts to plug into all of the latest news and science:

@drmarkhyman I @drjeffreybland I @functionhealth I @bigboldhealth

PS. Big Bold Health is sponsoring a giveaway contest through 6/17/2025. You could win a complete suite of products + a signed copy of Dr. Bland’s book, The Disease Delusion: Conquering the Causes of Chronic Illness for a Healthier, Longer, and Happier Life. You can enter via Instagram or with this LINK.